Exploratory Study of the Relationships Between the Biomarkers of Inflammation, Lipidome and Insulin Resistance and Disorders of Glycemic Regulation in a Cohort of Insulin-resistant Subjects Due to Excess Weight or Dunnigan's Lipodystrophy (IRAP-DUN 2)

C

Centre Hospitalier Universitaire de la Réunion

Status

Completed

Conditions

Dunnigan Syndrome
Lipodystrophy

Treatments

Other: research-specific blood sample

Study type

Interventional

Funder types

Other

Identifiers

NCT05424913
2017/CHU/07-2021-A00105-36

Details and patient eligibility

About

The objective of this work is to identify biomarkers of interest in patients with insulin resistance leading to early disorders of glycemic regulation. For this the investigators want to assay the insulin resistance marker Insulin Regulated Amino Peptidase serique (IRAPs), the plasma lipidome and inflammation markers in 2 populations of insulin-resistant subjects due to Dunnigan's inherited lipodystrophy or overweight/obesity and insulin-sensitive subjects with or without a glycemic regulation disorder objectified during an Oral induced hyperglycemia. The results of the IRAPs, lipidome and inflammation assays will be compared in insulin-resistant subjects, between normoglycemic, prediabetic and diabetic subjects. Correlations will be made between these markers and the deterioration of glycemic regulation as well as with known insulin resistance parameters (HOmeostasis Assessment Model (HOMA), Quantitative Insulin-sensitivity Check Index (QUICKI),Insulin Sensitivity Index (Isi) MATSUDA).

Enrollment

150 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Subjects with Dunnigan's Lipodystrophy OR Non-lipodystrophic insulin-resistant subjects OR Insulin-sensitive non-lipodystrophic subjects
  • major
  • Subjects benefiting from metabolic exploration in the Endocrinology, Diabetology and Nutrition department of the Reunion University Hospital.
  • Subject benefiting from an oral glucose tolerance test (OGTT) during his follow-up in the Endocrinology, Diabetology and Nutrition department of the Reunion University Hospital.
  • Person affiliated or beneficiary of a social security scheme.
  • Subject having been informed of the study in progress and having given their written consent.

Exclusion criteria

  • Pregnant woman
  • Person under guardianship or curators or deprived of liberty

Trial design

Primary purpose

Other

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

150 participants in 3 patient groups

Subjects with Dunnigan's Lipodystrophy
Other group
Treatment:
Other: research-specific blood sample
Non-lipodystrophic insulin-resistant subjects
Other group
Treatment:
Other: research-specific blood sample
Insulin-sensitive non-lipodystrophic subjects
Other group
Treatment:
Other: research-specific blood sample

Trial contacts and locations

0

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Central trial contact

Samir MEDJANE

Data sourced from clinicaltrials.gov

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