Explore the Impacts of One Session Theta Burst Stimulation Over Cerebellum in Adults With Autism Spectrum Disorder

Chang Gung Medical Foundation

Status: Active, not recruiting

Conditions: Autism Spectrum Disorder

Treatments: Device: intermittent theta burst stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05578261

202200409A0

Details and patient eligibility

About

The investigator would like to investigate the impact of theta-burst stimulation over cerebellum in adults with autism spectrum disorder

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults with autism spectrum disorder (≥18 years old), confirmed by Autism Diagnostic Observation Schedule.

Exclusion criteria

• Previous or current severe neurological disorder such as epilepsy, visual or hearing impairment.
• Previous or current severe systemic disease such as cardiovascular disease, diabetes or infection.
• Previous or current severe brain injury
• Implementation of metal materials such as pacemaker or medication pump
• Previous or current severe psychiatric disorders such as schizophrenia, bipolar disorder or substance abuse
• Pregnancy
• Individuals with a significant brain abnormality such as intracranial space occupied lesions
• History of brain surgery or nervous system infection, such as meningitis and encephalitis
• Concurrent use of medications which increased the risk of seizure attack
• Participate another clinical trial within one month
• Skin trauma on application site
• Individuals suffering from multiple sclerosis
• Individuals with a large ischemic scar
• Individuals suffering from sleep deprivation during rTMS procedures
• Individuals with a heavy consumption of alcohol
• Current taking antiepileptic drugs
• Individuals with a migraine headache from increased intracranial pressure
• Unable to complete MRI scan

Withdrawal criteria:

• Seizure attack during study period
• Autistic symptoms worsened obviously during study period
• Extreme agitation or irritability during study period
• Participants request
• Take antiepileptic drug during study period

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Active

Experimental group

Description:

All of the participants will accept one session iTBS over right Crus I/II. The total pulses of every session are 1200 pulses (600 pulses with 15 minutes interval) \*iTBS = intermittent theta burst stimulation.

Treatment:

Device: intermittent theta burst stimulation