Explore the Relationship Between Heart Rate Variability, Body Mass Index, Inflammation, and Insulin Resistance.

National Tainan Junior College of Nursing

Status: Completed

Conditions: Overweight; Insulin Resistance; Obesity

Treatments: Behavioral: aerobic exercise(AE)

Study type: Interventional

Funder types: Other

Identifiers

NCT05949710

NTJCN

Details and patient eligibility

About

The findings will serve as a reference for clinical professionals to promote exercise among the general population for improving HRV.

Full description

Background: Heart rate variability (HRV) measurement is widely used to assess the function of cardiac autonomic modulation. Aerobic exercise (AE) has been proven to improve HRV. However, because HRV is highly associated with visceral fat, inflammatory status, and insulin resistance, whether baseline body inflammation status can explain the heterogeneous response to AE remains unknown.

Purposes: We will compare the effects of AE training in improving HRV, inflammatory markers, and insulin resistance between community residents with normal weight and overweight/obesity.

Methods: A quasi-experimental study with purposive sampling will be used to recruit community residents aged 40-64 years with inactive habits in southern Taiwan. The minimum targeted sample size is 43 participants. The participants will be grouped into normal weight and overweight/obese groups. All participants will receive AE training with at least moderate intensity three times per week. HRV parameters, blood samples, and visceral fat will be evaluated. The blood samples will be evaluated for C-reactive protein and markers of insulin resistance (fasting glucose, insulin). All participants will be evaluated at baseline (T0) and after a 16-week intervention (T1). In addition to these time points, HRV will be measured during every exercise session for participants in exercise groups. Generalized estimating equations will be used to determine whether baseline BMI is the key factor influencing the effects of AE.

Relevance to clinical practice: The findings will serve as a reference for clinical professionals to promote exercise among the general population for improving HRV.

Enrollment: 51 patients

Sex: All

Ages: 40 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• are aged between 40 and 64 years.
• had inactive habit (<3 days of physical activity per week and <30 minutes per session).
• can communicate in Mandarin or Taiwanese.

Exclusion criteria

• underlying conditions, such as stroke, acute coronary artery diseases, handicap, pregnancy, and unstable hypertension, that may present risks for exercise training.
• smoking or alcohol abuse.
• currently being on a diet, and (d) lifestyles that may affect HRV and inflammatory biomarkers (e.g., shift work or habit of staying up late).

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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51 participants in 2 patient groups

aerobic exercise(AE), normal weight

Experimental group

Description:

3 times a week, normal weight

Treatment:

Behavioral: aerobic exercise(AE)

aerobic exercise(AE) , overweight/obese

Experimental group

Description:

3 times a week, overweight/obese

Treatment:

Behavioral: aerobic exercise(AE)