Exploring and Establishment of Combined Extracorporeal Life Support(CELS) in Critically Ill Children

Guoping Lu

Status: Withdrawn

Conditions: Critical Illness; MODS; Sepsis

Treatments: Other: Treatment

Study type: Observational

Funder types: Other

Identifiers

NCT03654287

fdpicu-02

Details and patient eligibility

About

Multiple organ failure (MODS) is still the leading cause of death in children in ICU. The treatment of MODS is mainly organ function monitoring and organ replacement therapy. Life support technology in vitro mainly includes mechanical ventilation, continuous renal replacement therapy (CRRT), non-biological artificial liver and extracorporeal membrane oxygenation technology (ECMO). However, critically ill patients who have multiple organ failure often require multiple organ support meanwhile. Combined extracorporeal life support (CELS) is still in its infancy to be applied in the treatment of critical illness due to nonstandard technology and theory without key breakthroughs and evidence-based medicine in the treatment of severe children organ failure.Solving the system problems supported by CELS can effectively reduce the mortality and disability rate of critically ill children and enhance health care in Shanghai, even across China.

Full description

The whole study is described below. To investigate the timing ,curative effect and mode of CRRT and ECMO treatment for critically ill children,we choose sepsis children especially those who are combined with septic shock as research object.

Furthermore,refractory shock is the therapeutic indications of ECMO. According to their clinical manifestation and severity of the disease,they are treated by CRRT or/with ECMO in a non-randomized way.

Comparing the laboratory index and prognosis of critically ill children treated by CRRT and those treated by ECMO,we aim to investigate the the timing ,curative effect of ECMO in the treatment of septic shock especially refractory shock.

The critically ill children who treated by CRRT are divided into three groups according to their treatment mode of CRRT. The laboratory index and prognosis are also be compared to investigate curative effect of CRRT in the treatment of septic shock.

The study also include severe sepsis children without CRRT or ECMO treatment as a control group.

Sex: All

Ages: 29 days to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children with severe sepsis and refractory shock admitted to the PICU of four study centers.

The informed consent of the guardians

Exclusion criteria

• active hemorrhage difficult catheter placing Irreversible brain damage patients enrolled in other clinic trial

Trial design

0 participants in 5 patient groups

Treatment with CPFA

Description:

The critically ill children who treated by CRRT and CRRT mode is decide as CPFA.

Treatment:

Other: Treatment

Treatment with TPE+CVVHDF

Description:

The critically ill children who treated by CRRT and CRRT mode is decide as TPE+CVVHDF.

Treatment:

Other: Treatment

Treatment with CVVHDF

Description:

The critically ill children who treated by CRRT and CRRT mode is decide as CVVHDF.

Treatment:

Other: Treatment

Treatment without CRRT/ECMO

Description:

The critically ill children who are not treated by CRRT or ECMO.

Treatment with ECMO

Description:

The critically ill children who are treated by ECMO whether treated by CRRT

Treatment:

Other: Treatment