Exploring the Acceptability and Efficacy of a Transdiagnostic Treatment for Misophonia

Duke University

Status: Completed

Conditions: Misophonia

Treatments: Behavioral: Revised Unified Protocol for Transdiagnostic Treatment of Emotional Disorders; Behavioral: Unified Protocol for Transdiagnostic Treatment of Emotional Disorders

Study type: Interventional

Funder types: Other

Identifiers

NCT04612374

Pro00106807

Details and patient eligibility

About

Despite increasing recognition of misophonia, there are currently no evidence-based treatments to help those who are suffering. Therefore, the primary purpose of this study is to assess the acceptability, feasibility, and preliminary efficacy of a treatment for misophonia. This study will be conducted in two phases. In the Phase 1, participants will receive a treatment the investigators believe can help manage symptoms of misophonia: The Unified Protocol. This treatment uses evidence-based psychological principles (e.g., managing attention or behavior) in a flexible manner and will focus on developing skills to help reduce the distress and impairment associated with Misophonia. After treatment, patients will provide feedback about their experience. The investigators will use this feedback to revise the treatment as indicated. In Phase 2, participants will receive the revised treatment and provide feedback on their experience. Throughout treatment in either phase, participants will provide daily and weekly information about their symptoms.

The aims of this study are (1) to explore the acceptability and feasibility of the Unified Protocol for individuals who experience Misophonia and (2) to examine whether this treatment helps reduce symptoms associated with Misophonia.

Enrollment: 18 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Between age 18-65
• Able to read English
• Meet criteria for interfering symptoms of misophonia
• Live in North Carolina

Exclusion criteria

• Under age 18 or over age 65
• Current mania
• Current psychotic disorder
• Current anorexia
• Presents with a condition that requires immediate prioritization in treatment (e.g., suicide planning or intent)

Phase 1 participants cannot also participate in Phase 2.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 4 patient groups

Phase 1: Unified Protocol, 2 week baseline

Experimental group

Description:

Participants in this arm will complete two weeks of baseline assessment (during which they will complete questionnaires but not start treatment) and then receive 16 sessions of the Unified Protocol (UP). The UP is an emotion-focused treatment designed to teach participants skills to help manage difficult experiences.

Treatment:

Behavioral: Unified Protocol for Transdiagnostic Treatment of Emotional Disorders

Phase 1: Experimental: Unified Protocol, 4 week baseline

Experimental group

Description:

Participants in this arm will complete four weeks of baseline assessment (during which they will complete questionnaires but not start treatment) and then receive 16 sessions of the Unified Protocol (UP). The UP is an emotion-focused treatment designed to teach participants skills to help manage difficult experiences.

Treatment:

Behavioral: Unified Protocol for Transdiagnostic Treatment of Emotional Disorders

Phase 2: Revised Unified Protocol, 2 week baseline

Experimental group

Description:

Participants in this arm will complete two weeks of baseline assessment (during which they will complete questionnaires but not start treatment) and then receive 16 sessions of the revised Unified Protocol (UP). The UP is an emotion-focused treatment designed to teach participants skills to help manage difficult experiences and will be revised based on patient feedback in Phase 1.

Treatment:

Behavioral: Revised Unified Protocol for Transdiagnostic Treatment of Emotional Disorders

Phase 2: Revised Unified Protocol, 4 week baseline

Experimental group

Description:

Participants in this arm will complete four weeks of baseline assessment (during which they will complete questionnaires but not start treatment) and then receive 16 sessions of the revised Unified Protocol (UP). The UP is an emotion-focused treatment designed to teach participants skills to help manage difficult experiences and will be revised based on patient feedback in Phase 1.

Treatment:

Behavioral: Revised Unified Protocol for Transdiagnostic Treatment of Emotional Disorders