Exploring the Cortical Hemodynamic Response of Excitatory Brain Stimulation: a Pilot Study

The Hong Kong Polytechnic University

Status: Completed

Conditions: Healthy

Treatments: Device: Intermittent theta-burst stimulation (iTBS)

Study type: Interventional

Funder types: Other

Identifiers

NCT05427552

HSEARS20200120005-01

Details and patient eligibility

About

Intermittent theta-burst stimulation (iTBS) is a promising treatment for major depressive disorder. However, fewer than 50% of patients show sufficient response. Therefore, the optimal treatment protocol is worth investigating. Recent studies show that the relationship between stimulation intensity and prefrontal hemodynamic response is not linear but in an inverse U-shape by exploring the hemodynamic changes before and after iTBS. Concurrent transcranial magnetic stimulation (TMS)/functional near-infrared spectroscopy (fNIRS) setup allows the investigators to observe the prefrontal hemodynamic response during stimulation.

The aim of this study is to investigate the effects of different intensities on brain activity during and after the stimulation using fNIRS.

Full description

Please refer to the full proposal

Enrollment: 24 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Right-handed

Exclusion criteria

• history of epilepsy, seizures, or convulsions
• current or past diagnosis of neurological disorders, such as head injuries, strokes, encephalitis, epilepsy, Parkinson's, or Alzheimer's
• current or past diagnosis of psychiatric disorders, such as depression, anxiety, schizophrenia, or autism
• with metal implants, such as a cochlear implant, neurostimulator, or cardiac pacemaker

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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24 participants in 3 patient groups

Prefrontal hemodynamic response to 50% rMT iTBS

Experimental group

Description:

Participants will receive 50% rMT iTBS over left DLPFC in this arm. The prefrontal hemodynamic response will be observed simultaneously before, during, and after iTBS using fNIRS.

Treatment:

Device: Intermittent theta-burst stimulation (iTBS)

Prefrontal hemodynamic response to 70% rMT iTBS

Experimental group

Description:

Participants will receive 70% rMT iTBS over left DLPFC in this arm. The prefrontal hemodynamic response will be observed simultaneously before, during, and after iTBS using fNIRS.

Treatment:

Device: Intermittent theta-burst stimulation (iTBS)

Prefrontal hemodynamic response to 90% rMT iTBS

Experimental group

Description:

Participants will receive 90% rMT iTBS over left DLPFC in this arm. The prefrontal hemodynamic response will be observed simultaneously before, during, and after iTBS using fNIRS.

Treatment:

Device: Intermittent theta-burst stimulation (iTBS)