Exploring the Links Between Hearing, Cognition and Brain Activity in People With Tinnitus (GHOSTTONE)

Pasteur Institute

Status: Not yet enrolling

Conditions: Tinnitus

Treatments: Behavioral: Attention task; Other: Quality of Life questionnaires; Other: Hearing tests; Behavioral: Auditory prediction task

Study type: Interventional

Funder types: Industry; Other

Identifiers

NCT06940726

2025-A00267-42 (Other Identifier)

2024-159

Details and patient eligibility

About

The goal of this observational study is to understand the mechanisms underlying tinnitus, and improve the clinical assessment strategies needed to develop targeted therapeutic interventions by comparing endogenous attention capacities in healthy subjects and subjects with tinnitus

Enrollment: 114 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Good written and oral comprehension of the French language
• Normal or corrected vision

Group of people with tinnitus :

• Chronic tinnitus > 3 months, uni or bilateral, stable (no period of remission)

Control group :

• No tinnitus

Exclusion criteria

• Presence of a known neurological disorder
• Presence of a known degenerative pathology
• Presence of a known hearing impairment
• Presence of a motor disability of the upper limbs
• Severe or profound deafness on one or both sides
• Person under legal protection (guardianship, curatorship, etc.)
• Use of hearing aids

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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114 participants in 2 patient groups

Healthy subjects

Sham Comparator group

Treatment:

Behavioral: Auditory prediction task

Other: Hearing tests

Other: Quality of Life questionnaires

Behavioral: Attention task

Subjets with tinnitus

Experimental group

Treatment:

Behavioral: Auditory prediction task

Other: Hearing tests

Other: Quality of Life questionnaires

Behavioral: Attention task