Exploring the Potential Benefits of Probiotic Yogurt

Wecare Probiotics

Status: Enrolling

Conditions: Chronic Constipation

Treatments: Dietary Supplement: Probiotic yogurt group; Dietary Supplement: Yogurt control group

Study type: Interventional

Funder types: Industry

Identifiers

NCT06847919

WK20250207

Details and patient eligibility

About

This study aims to evaluate the effect of a high-activity probiotic yogurt on improving symptoms of chronic constipation, observing its regulatory effects on the gut microbiota and the incidence of adverse reactions in study participants over a 21-day intervention period.

Enrollment: 84 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Meet the Rome IV diagnosis criteria for chronic constipation;
2. Patients who are able to understand clinical studies and are committed to complying with study requirements and procedures;
3. Age 18-65. -

Exclusion criteria

1. Systemic (diabetes, autoimmune diseases, cancer), gastrointestinal or liver diseases known to be associated with alterations in the gut microbiota;
2. Patients who are pregnant or lactating;
3. have taken antimicrobials, probiotics, or drugs that inhibit stomach acid or gastrointestinal motility in the past 6 weeks;
4. Patients who changed their diet type during the study;
5. Patients who are allergic or intolerant to any component of the investigational product formulation;
6. Patients with cardiovascular, cerebrovascular, liver, kidney and hematopoietic system and other serious diseases and endocrine diseases, mental patients;
7. Stop taking the tested sample or add other drugs in the middle, unable to judge the efficacy or incomplete data;
8. short-term use of objects related to the function of the test, affecting the judgment of the result;
9. have been dieting, exercising excessively, taking weight loss medications or taking medications that may affect appetite in the past 3 months;
10. Current or past excessive use of alcohol, drugs, or supplements that may cause intestinal dysfunction or interfere with the evaluation of the efficacy of the study product -

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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84 participants in 2 patient groups, including a placebo group

Probiotic group

Active Comparator group

Description:

Bacterial count: ≥1000 billion CFUs per bottle Take one bottle of yogurt per day for 3 weeks

Treatment:

Dietary Supplement: Probiotic yogurt group

Placebo group

Placebo Comparator group

Description:

Product name: placebo yogurt Take one bottle of yogurt per day for 3 weeks

Treatment:

Dietary Supplement: Yogurt control group