Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises

Soroka University Medical Center

Status: Unknown

Conditions: Healthy

Study type: Observational

Funder types: Other

Identifiers

NCT00660465

SOR467608CTIL

Details and patient eligibility

About

The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .

Full description

Among many parameters effecting cerebral blood flow(CBF), partial pressure of CO2 (PaCO2) in arterial blood has a significant effect. A small increase in arterial PaCO2 level will cause a significant increase of CBF , followed by increase of O2 level . The main objective is to explore the effect of arterial PaCO2 level on regional CBF and brain O2 level, by using breathing exercises to modulate arterial PaCO2. The regional Blood Oxygen Level Dependent (BOLD) signal produced by MRI , will indicate the regional O2 level.

Enrollment: 6 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adults over 18 years old .

Exclusion criteria

• under 18 years old.
• Artificial pacemaker
• implantable cardioverter-defibrillator (ICD)
• Hearing aid, implantable or portable.
• artificial heart valve
• Surgical clips
• Metal fragments in eyes
• Electronic stimulators
• Implanted pumps
• Implantable Neurostimulation Device
• metal fragments of any sort
• Permanent makeup or tattoo
• transfusion pump
• pregnant or breast feeding women
• False teeth , retainer or dental crown

Trial design

6 participants in 1 patient group

A18