Exploring the Role of Magnesium in Rest Cramps

University of British Columbia

Status: Completed

Conditions: Rest Cramps

Treatments: Drug: Intravenous Infusion of Magnesium Sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT00423540

Health Canada #9427-R1243-21C

H06-03345

Details and patient eligibility

About

This study sets out to show whether infusions of magnesium can lessen the frequency of rest cramps and to determine whether rest cramp sufferers have a deficiency in magnesium.

Full description

Subjects will be randomized to receive 5 days of 4 hour IV infusions of D5W either with or without 20 mmol magnesium sulfate added. Twenty four hour urinary excretion of magnesium will be determined on the first day of infusions to assess whether magnesium deficiency is present. Ten normal controls will also undergo a single infusion and collection of urine to serve as a comparison group for the urinary excretion data.

Enrollment: 54 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ≥2 leg or foot cramps per week in a 4 week run-in diary

Exclusion criteria

• eGFR<50
• Neurologic disease
• Pregnancy
• Heart block
• Bradyarhythmia without pacemaker
• Digoxin use
• Liver disease
• Addison's disease
• History of MI
• CHF
• Absence of detectable reflexes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind