Exposure to Potential Cytochrome P450 Pharmacokinetic Drug-Drug Interactions Among Osteoarthritis Patients: Incremental Risk of Multiple Prescriptions

NEMA Research

Status: Completed

Conditions: Chronic Low Back Pain

Study type: Observational

Funder types: Industry

Identifiers

NCT01177254

CYP450OA1

Details and patient eligibility

About

Using a retrospective analysis of a large commercial claims database and a Medicare database, the investigators evaluated DDEs that have the potential to cause DDIs among chronic low back pain (cLBP) patients on long-term opioid analgesia, which metabolizes through the CYP450 enzyme system, concomitant with other CYP450-metabolized drug(s).

Enrollment: 10,000 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• chronic low back pain

Exclusion criteria

• pregnancy