Expression and the Clinical Significance of Neutrophil PD-L1 During Sepsis

Naval Military Medical University

Status: Completed

Conditions: Immunosuppression; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT01976884

NeutrophilPD-L1

Details and patient eligibility

About

Immunosuppression is the leading cause of death in septic patients. Neutrophils are classical components of innate immunology, but recent studies showed that neutrophils might display antigen presenting function and inhibit lymphocyte proliferation by expressing programmed cell death 1 ligand 1 (PD-L1). Whether neutrophils express PD-L1 and its role in immunosuppression during sepsis remain unclear.

Enrollment: 71 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with severe sepsis
• patients with sepsis after PCNL for infectious kidney stone
• patients with pancreatic cancer
• healthy volunteers

Exclusion criteria

• patients with immunodeficient diseases
• patients who accept glucocorticoid or immunosuppressant
• patients with an age older than 18 years
• patients providing the informed consent

Trial design

71 participants in 4 patient groups

Severe sepsis

Description:

Patients with severe sepsis

Infectious kidney stone

Description:

Patients with sepsis after PCNL for infectious kidney stone

Tumor

Description:

Patients with pancreatic cancer

Volunteer