Expression Levels of microRNA Processing Enzymes Dicer and Drosha in Epithelial Skin Cancer

Ruhr University of Bochum

Status: Completed

Conditions: Skin Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT00849914

005

Details and patient eligibility

About

MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the expression profiles for the two most important miRNA processing enzymes Dicer and Drosha of actinic keratoses, basal cell carcinoma and squamous cell carcinoma are compared to healthy skin tissue.

Enrollment: 28 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with actinic keratoses, squamous cell carcinoma or basal cell carcinoma of the skin

Exclusion criteria

• Patients under 18 years of age
• Patients with other forms of cancer in previous medical history

Trial design

28 participants in 3 patient groups

1

Description:

Patients with actinic keratoses of the skin

2

Description:

Patients with basal cell carcinoma of the skin

3

Description:

Patients with squamous cell carcinoma of the skin