Expression Levels of Nicotinamide Metabolism-related Protein (NMAP) in Newly Diagnosed Renal Cancer and Non-renal Cancer Populations (ENRC)

Shanghai Jiao Tong University

Status: Unknown

Conditions: Carcinoma, Renal Cell

Treatments: Other: Blood test

Study type: Observational

Funder types: Other

Identifiers

NCT04113486

XHEC-C-2019-104

Details and patient eligibility

About

This study aims to observe the difference between NMAP (nicotinamide metabolism associated protein) serum levels in primary diagnosed renal cancer patients and non-renal cancer patient controls, plot the ROC curve and establish appropriate cut-off values.

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. The tumor group patients were found to have renal or hepatic mass, plan to receive surgical treatment (except for radiofrequency ablation, cryoablation, etc., which were not available for pathological examination). The control group patients were ruled out of tumor based on radiological tests and commonly used tumor biomarkers
2. Age ≥ 18 years old and able to provide written informed consent;
3. Have not received any systemic or topical treatment for kidney/liver tumors.
4. Cardiopulmonary, liver and kidney functions are able to tolerate surgery and can comply with research requirements.

Exclusion criteria

1. The investigators believe that the subject may be unsuitable for inclusion due to severe concurrent diseases, infections, and etc.
2. The subjects is known or suspected of other malignancies.
3. There has been another history of malignancy in the past 5 years.
4. Major surgery (surgery requiring general anesthesia) was performed within 4 weeks prior to screening visits.

Trial design

400 participants in 4 patient groups

Renal cancer group

Description:

Patients which imaging studies have found renal mass, plan to receive surgery (except for radiofrequency ablation, cryoablation, etc.), about 100.

Treatment:

Other: Blood test

Urothiasis group

Description:

Patients which imaging studies have found renal or ureteral stones, and rule out of renal mass, about 100.

Treatment:

Other: Blood test

Renal cysts group

Description:

Patients which imaging studies have found renal cysts (simple or complex) about 100.

Treatment:

Other: Blood test

Liver cancer group

Description:

Patients which imaging studies have found hepatic mass, plan to receive surgery (except for radiofrequency ablation, cryoablation, etc.), about 100.

Treatment:

Other: Blood test