Expression of CD44, PCNA and E-cadherin in Pterygium Tissue

Balikesir University

Status: Not yet enrolling

Conditions: Pterygium

Treatments: Other: Expression of CD44, E-cadherin and PCNA

Study type: Observational

Funder types: Other

Identifiers

NCT06042296

BAUNHYILDIRIM-1

Details and patient eligibility

About

Purpose: Pterygium is a common ocular surface disease defined by fibrovascular conjunctival growth extending onto the cornea. Its pathogenesis remains unclear. In severe cases, it may extend into the central cornea, inducing irregular corneal astigmatism and causing loss of vision. CD44( phagocytic glycoprotein-1 ) is involved in the organization of certain cellular processes, for instance, cell adhesion, division, and migration, by binding with its main ligand, hyaluronic acid. Proliferating cell nuclear antigen (PCNA) is a proliferation marker in the nucleus. E-cadherin is a calcium-dependent transmembrane glycoprotein that plays a significant role in the protection of tissue integrity and cell-to-cell adhesion. This study aimed to determine the role of CD44, proliferating cell nuclear antigen (PCNA), and E-cadherin in pterygium formation and recurrence.

Full description

Methods:60 patients with pterygium will be enrolled in the study and conjunctival samples will be collected from 30 patients to form the control group. CD44, PCNA and E-cadherin expressions in surgically removed pterygium will be compared with tissue samples from normal control group.

IBM SPSS (statistical software) version 26.0 will be used for statistical analyses.

Enrollment: 60 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: patient with pterygium -

Exclusion Criteria: patient with pseudopterygium

Trial design

60 participants in 3 patient groups

control group

Description:

group 1 -control group normal conjunctiva from 30 patients

Treatment:

Other: Expression of CD44, E-cadherin and PCNA

group 2 primary pterygia

Description:

primary pterygia samples from 30 patients

Treatment:

Other: Expression of CD44, E-cadherin and PCNA

group 3 recurrent pterygia

Description:

recurrent pterygia samples from 30 patients

Treatment:

Other: Expression of CD44, E-cadherin and PCNA