Expression of DMBT1 in Colorectal Cancer Patients

Lille Catholic University

Status: Completed

Conditions: DMBT1 Protein, Human; Colorectal Cancer

Treatments: Other: Detection of the expression of DMTB1 by immunohistochemistry

Study type: Observational

Funder types: Other

Identifiers

NCT02901600

RT-06

Details and patient eligibility

About

Although colorectal cancer is a preventable and curable disease if early stage tumors are removed, it is still the fourth cause of cancer worldwide and the second leading cause of death in many industrialized countries. The 5-year survival is about 55% often due to a late detection. Then, the identification of sensitive and specific molecular markers is therefore a major challenge for early diagnosis and prognosis of this disease.

Preliminary work have reported variations in the expression of DMBT1 (deleted in malignant brain tumor 1), a glycoprotein co-secreted with mucins in the light of the glands, during several stages of colon carcinogenesis. The goal of this study is to study by mass spectrometry (MS), alterations in the repertoire of glycosylation of mucins from colorectal tumors of various stages, grades, and recurrence status.

Enrollment: 145 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• for colon cancer: patients surgically treated for colorectal cancer at the Group of hospitals of the Catholic Institute of Lille.
• for adenomatous polyps : patients treated for adenomatous polyps at the Group of hospitals of the Catholic Institute of Lille.
• for controls: patients surgically treated for diverticular disease at the Group of hospitals of the Catholic Institute of Lille.

Exclusion criteria

• none

Trial design

145 participants in 3 patient groups

Patients with colorectal cancer

Description:

Fresh tissue samples from individuals with colorectal carcinoma taken from the tumor as well as from resection margins will be used for the detection of a potential marker of carcinogenesis.

Treatment:

Other: Detection of the expression of DMTB1 by immunohistochemistry

Patients with adenomatous polyps

Description:

Fresh tissue samples from individuals with adenomatous polyps will be used for the detection of a potential marker of carcinogenesis.

Treatment:

Other: Detection of the expression of DMTB1 by immunohistochemistry

Control patients

Description:

Fresh tissue samples from individuals without colorectal carcinoma will be used as control.

Treatment:

Other: Detection of the expression of DMTB1 by immunohistochemistry