Expression of HOXA10 and HOXA11 in the Endometrium of Infertility Patients With an Endometrial Polyp Before and After Polypectomy

H

Hillel Yaffe Medical Center

Status

Unknown

Conditions

Infertility

Treatments

Procedure: Endometrial biopsy

Study type

Interventional

Funder types

Other

Identifiers

NCT02761278
HYMC-0039-16

Details and patient eligibility

About

The aim of this study is to measure the expression of HOXA10 and HOXA11 in the endometrium of infertility patients with an endometrial polyp before and after polypectomy. HOXA10 and HOXA11 are well-established markers of implantation. It is uncertain as to whether an endometrial polyp interferes with embryo implantation. A higher expression of HOXA10 and HOXA11 after polypectomy can indicate that endometrial polyp does interfere with embryo implantation.

Enrollment

20 estimated patients

Sex

Female

Ages

20 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Infertile women with endometrial polyp

Exclusion criteria

  • Endometriosis
  • Polycystic ovary syndrome
  • Hydrosalpinx
  • Sub-mucus myoma
  • Women who have taken hormonal therapy in the preceding month

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

20 participants in 2 patient groups

HOXA10 and HOXA11 Expression Before Polypectomy
Active Comparator group
Description:
A biopsy will taken in infertility patients with endometrial polyp before polypectomy
Treatment:
Procedure: Endometrial biopsy
HOXA10 and HOXA11 Expression After Polypectomy
Active Comparator group
Description:
A biopsy will taken in infertility patients with endometrial polyp 1-3 months after polypectomy
Treatment:
Procedure: Endometrial biopsy

Trial contacts and locations

0

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Central trial contact

Guy Shrem, MD

Data sourced from clinicaltrials.gov

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