Expression of HOXA10 and HOXA11 in the Endometrium of Infertility Patients With an Endometrial Polyp Before and After Polypectomy

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Infertility

Treatments: Procedure: Endometrial biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT02761278

HYMC-0039-16

Details and patient eligibility

About

The aim of this study is to measure the expression of HOXA10 and HOXA11 in the endometrium of infertility patients with an endometrial polyp before and after polypectomy. HOXA10 and HOXA11 are well-established markers of implantation. It is uncertain as to whether an endometrial polyp interferes with embryo implantation. A higher expression of HOXA10 and HOXA11 after polypectomy can indicate that endometrial polyp does interfere with embryo implantation.

Enrollment: 20 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infertile women with endometrial polyp

Exclusion criteria

• Endometriosis
• Polycystic ovary syndrome
• Hydrosalpinx
• Sub-mucus myoma
• Women who have taken hormonal therapy in the preceding month

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

HOXA10 and HOXA11 Expression Before Polypectomy

Active Comparator group

Description:

A biopsy will taken in infertility patients with endometrial polyp before polypectomy

Treatment:

Procedure: Endometrial biopsy

HOXA10 and HOXA11 Expression After Polypectomy

Active Comparator group

Description:

A biopsy will taken in infertility patients with endometrial polyp 1-3 months after polypectomy

Treatment:

Procedure: Endometrial biopsy