Expression of IRAK1 Gene rs1059703-related Single- Nucleotide Polymorphisms in Egyptian Patient With Rheumatoid Arthritis

Sohag University

Status: Enrolling

Conditions: Rheumatoid Arthritis (RA)

Treatments: Genetic: PCR polymorphism

Study type: Interventional

Funder types: Other

Identifiers

NCT05588817

Soh_Med_22_10_15

Details and patient eligibility

About

Rheumatoid arthritis (RA) is known as a long-lasting inflammatory autoimmune disease affecting the diarthrodial joints, which is diagnosed by inflammation and hyperplasia in synovium, generation of RF and anti-citrullinated protein antibody (ACPA), deformity of cartilage and bone, systemic injuries involving cardiovascular, pulmonary, psychological, and skeletal disorders (McInnes and Schett., 2011).

Enrollment: 90 estimated patients

Sex: Female

Ages: 17 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• approval to sign an informed written consent, patient diagnosed rheumatoid arthritis, patient age range 17-85 year and both sexes are included.

Exclusion criteria

• Refusal to sign an informed written consent and patient with other autoimmune disease.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 2 patient groups

Group 1

Active Comparator group

Description:

Normal control

Treatment:

Genetic: PCR polymorphism

Group 2

Active Comparator group

Description:

Diagnosed Rhomatoid arthritis patients

Treatment:

Genetic: PCR polymorphism