Expression of Optic Atrophy Type 1 (OPA1) Protein in Lung Adenocarcinoma

China Medical University

Status: Unknown

Conditions: Lung Adenocarcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT01249053

DMR99-IRB-062

Details and patient eligibility

About

Optic atrophy type 1(OPA1) is a nuclear dynamin-related GTPase, targeted to the inner mitochondrial membrane, which plays a role in mitochondrial fusion. Mitochondria fusion is associated with process of apoptosis. . OPA1 plays an important role in the mitochondrial bioenergetics and mitochondrial networks. The changes in mitochondrial shape and mitochondrial bioenergetics may be cause of the disease. In this study, we investigate the expression of OPA1 in lung adenocarcinoma (LADC) cells and tissue.

Enrollment: 100 estimated patients

Sex: All

Ages: 25 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• We will collect paraffin blocked resected lung tissue samples from stage I~IIIa non-small cell lung cancer patients (age, 40~80 years old) who received lobectomy of the affected lung.

Exclusion criteria

• History of uremia, other malignant disease, and liver cirrhosis
• History of pneumonia and pulmonary tuberculosis
• History of long period of medications.