Expression of the Inhibitory Receptors on Lymphocytes T Cells After Lung Cancer Surgery. (POIR)

Centre Hospitalier Universitaire de Saint Etienne

Status

Completed

Conditions

Surgery

Lung Cancer

Treatments

Biological: Blood samples

Study type

Interventional

Funder types

Other

Identifiers

NCT03549546

2017-A03391-52 (Other Identifier)

1708182

Details and patient eligibility

About

Postoperative pneumonia is one of the most common complications after lung cancer surgery and associated with a morbidity and mortality. Postoperative lymphopenia has been recently identified as one of risk factors for postoperative pneumonia. According to recent studies in polytrauma, cancer or septic shock, T cells dysfunction may be related to high expression of inhibitory receptors on lymphocytes.

Full description

This study will investigate prospectively TIM-3, PD-1 and CTLA4 expression on lymphocytes T cells before and after lung cancer surgery. Patients ≥ 18 years with no history of immunosuppressive state will be included.

Enrollment

31 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient ≥ 18 years undergoing lung cancer surgery by thoracoscopy

Exclusion criteria

Patient under guardianship/curatorship
Patient who received of radiotherapy or chemotherapy in the last 6 months
Patient under immunosuppressive treatment or dose of corticoids over 10 mg/day prednisolone or equivalent
Patient with history of malignant blood disease or auto-immune disease
Patient suffering from HIV infection and
Patients with pre-operative infection
Patient with an empiric antibiotic therapy introduced at operating room