Expression of TIM-3 on Lymphocytes in Sepsis

Naval Military Medical University

Status: Unknown

Conditions: Immunosuppression; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT02319876

81201492 (Other Grant/Funding Number)

TIM3-SEPSIS

Details and patient eligibility

About

The current project was designed to examine the express TIM-3 on lymphocytes and monocytes and its role in immunosuppression during sepsis.

Full description

Immunosuppression is the leading cause of death in septic patients.Lymphocyte apoptosis has been recognized as an important step in the pathogenesis of sepsis. Previous studies indicated that T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein and was identified as a marker of lymphocyte dysfunction. The current project was designed to examine the express TIM-3 on lymphocytes and monocytes and its further role in immunosuppression during sepsis.

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with severe sepsis
• patients undergo invasive spine surgery
• healthy volunteers

Exclusion criteria

• patients with immunodeficient diseases
• patients who accept glucocorticoid or immunosuppressant
• patients with an age older than 18 years
• patients providing the informed consent

Trial design

80 participants in 3 patient groups

Severe sepsis

Description:

Patients with severe sepsis

SIRS patient

Description:

Patients after elective surgeries presented with SIRS but without sepsis

Volunteer

Description:

Volunteers