Extended Work Schedules, Sleep Loss and Health (EW and EWD)

The University of Chicago

Status: Completed

Conditions: Sleep

Treatments: Behavioral: Fixed restricted bedtimes; Behavioral: Sleep restriction with circadian misalignment

Study type: Interventional

Funder types: Other

Identifiers

NCT00989534

11403A

Details and patient eligibility

About

This study aims to determine whether abnormal bodily rhythms contribute to elevate the risk of diabetes, independently of the amount of sleep loss.

Enrollment: 49 patients

Sex: All

Ages: 21 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• normal healthy men and women between the ages of 21 years and 39 years (inclusive) with normal weight (i.e., body mass index under 28 kg/m2 in men, 27 kg/m2 in women)
• normal findings on clinical examination, normal results on routine laboratory tests, normal EKG, normal glucose tolerance test, negative pregnancy test for women
• no personal history of psychiatric or endocrine illness
• no personal history of sleep disorder, usual total sleep time of at least 7 hours
• only female volunteers with normal ovulatory cycles will be included

Exclusion criteria

• subjects with irregular life habits (shiftworkers and subjects having traveled across time zones less than one month prior to the beginning of the baseline study)
• subjects taking any medication (including hormonal contraceptive therapy), and smokers are excluded
• subjects with significant sleep apnea (apnea index above 10) or significant arousal-associated periodic leg movements are excluded

Trial design

49 participants in 2 patient groups

Sleep loss and circadian alignment

Experimental group

Description:

Sleep restriction without circadian misalignment

Treatment:

Behavioral: Fixed restricted bedtimes

Sleep loss and circadian misalignment

Experimental group

Treatment:

Behavioral: Sleep restriction with circadian misalignment