Extent of Lymph Node Dissection for Advanced Right-Sided Colon Cance (MARCH)

Sun Yat-sen University

Status: Not yet enrolling

Conditions: Advanced Right-sided Colon Cancer; the Extent of Lymph Node Dissection

Treatments: Procedure: Clearance with the left side of the SMV as the medial boundary; Procedure: Clearance with the left side of the SMA as the medial boundary

Study type: Interventional

Funder types: Other

Identifiers

NCT06986538

MARCH

Details and patient eligibility

About

This is a prospective multicenter randomized controlled clinical study to explore the extent of lymph node dissection in progressive right hemicolon cancer and to elucidate the pattern of lymphatic drainage in the right hemicolon.

Enrollment: 1,064 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age: 18-75 years
2. Preoperative pathologic confirmation of adenocarcinoma
3. Tumor located in the region from the ileocecal valve to the right one-third of the transverse colon
4. American Society of Anesthesiologists (ASA) physical status classification I to III
5. Patients who have not received preoperative radiotherapy, chemotherapy, or immunotherapy
6. Preoperative imaging staging cT4N0M0 or cT3-4N+M0
7. Willing to participate in the study and sign the informed consent form

Exclusion criteria

1. Past medical history of malignant tumor
2. Patients with multiple primary tumors
3. Patients with a history of inflammatory bowel disease or familial adenomatous polyposis
4. Patients with distant metastasis
5. Pregnant or breastfeeding women
6. History of other previous major abdominal surgery
7. Patients requiring emergency surgery (including tumor perforation, obstruction, hemorrhage, etc.)
8. Those with other clinical and laboratory conditions deemed by the investigator to be inappropriate for participation in the trial

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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1,064 participants in 2 patient groups

SMV group

Active Comparator group

Treatment:

Procedure: Clearance with the left side of the SMV as the medial boundary

SMA group

Experimental group

Treatment:

Procedure: Clearance with the left side of the SMA as the medial boundary