External Validation of a Septic Arthritis Prognosis Score (SYNOLACTATES +)

Rennes University Hospital

Status: Completed

Conditions: Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT03819855

35RC18_30015_SYNOLACTATES-PLUS

Details and patient eligibility

About

Observational study

Full description

Septic arthritis is a diagnostic emergency for acute arthritis because it is accompanied by an excess of mortality of 11% and frequent functional sequelae in about 50% of cases in the year. However, it remains rare with an estimated annual incidence of 1 to 5/100000, and a prevalence of about 10% in front of an acute arthritis table sent to an emergency department.

The diagnosis is based on the bacteriological culture which finds the presence of a microorganism within the joint. However, only 80% of septic arthritis is bacteriologically documented due to low inoculum, the presence of fragile bacteria (Neisseria sp) or especially untimely antibiotherapy prior to joint puncture.

In addition, the bacteriological culture takes an average of 3 days to become positive, which may delay the implementation of appropriate antibiotic therapy.

It is therefore essential that the clinician can rely on other clinical or biological parameters, reliable and fast for better diagnostic orientation.

A first study: SYNOLACTATES showed the interest of the measurement of glucose and synovial lactate for the diagnosis of septic arthritis with very good performances. A RESAS score (REnnes Septic Arthritis Score) was constructed from these results to assess the likelihood of septic arthritis.

Enrollment: 244 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any acute arthritis less than or equal to 30 days;
• Achievement of a joint puncture in routine care as part of the diagnostic assessment of this acute arthritis;
• Affiliation to a social security scheme;
• No one opposes his participation in the research.

Exclusion criteria

• Age below 18 years;
• Major persons subject to legal protection (safeguard of justice, guardianship, guardianship), persons deprived of their liberty.