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Extinction Learning in Adults With Tourette Syndrome

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Johns Hopkins University

Status

Completed

Conditions

Tourette Syndrome
Comprehensive Behavioral Intervention for Tics
Habit Reversal Training
Tics
Tic Disorders

Treatments

Behavioral: Habit Reversal Training

Study type

Interventional

Funder types

Other

Identifiers

NCT04498364
IRB00256962

Details and patient eligibility

About

Aversive sensory phenomena such as premonitory urges play a central role in the behavioral treatment model of tics. Extinction learning and extinction recall are learning processes implicated within this model, but are still understudied for individuals with Tourette syndrome (TS). This study examines extinction learning and extinction recall in adults with TS using an experimental task. This study will also explore the relationship between extinction processes (i.e., extinction learning and extinction recall) and treatment outcomes with behavior therapy. Findings from this investigation will be used to update the behavioral treatment model, which serves as the basis for evidence-based behavioral interventions.

Enrollment

10 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • At least 18 years old,
  • Have moderate tic severity or greater as evidenced by a YGTSS Total Tic Score greater than 13 (>9 for youth with motor or vocal tics only)
  • Have not received more than 4 previous sessions of HRT
  • Be fluent in English
  • Medication free or on a stable dose of psychiatric medication for 8 weeks prior to enrollment.

Exclusion criteria

  • An inability to complete rating scales
  • An inability to attend study visits

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

10 participants in 1 patient group

Habit Reversal Training
Experimental group
Description:
Habit Reversal Training (HRT) is a multi-component evidence-based treatment for tics. It will be delivered over 8 hours of treatment.
Treatment:
Behavioral: Habit Reversal Training

Trial contacts and locations

1

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Central trial contact

Nicholas Myers

Data sourced from clinicaltrials.gov

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