Extinction Learning in Youth With Tourette Syndrome

Johns Hopkins University

Status: Completed

Conditions: Tourette Syndrome in Adolescence; Tourette Syndrome in Children; Habit Reversal Training; Tic

Treatments: Behavioral: Habit Reversal Training

Study type: Interventional

Funder types: Other

Identifiers

NCT03765463

IRB00195059

Details and patient eligibility

About

Aversive sensory phenomena such as premonitory urges play a central role in the behavioral treatment model of tics. Extinction learning and extinction recall are learning processes implicated within this model, but have not been directly evaluated in youth with Tourette syndrome (TS). This study examines extinction learning and extinction recall in youth with TS using an experimental task. This study will also explore the relationship between extinction processes (i.e., extinction learning and extinction recall) and treatment outcomes with behavior therapy. Findings from this investigation will be used to update the behavioral treatment model, which serves as the basis for evidence-based behavioral interventions.

Enrollment: 20 patients

Sex: All

Ages: 8 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Youth with TS will be eligible for participation if they meet the following inclusion criteria:

• age 8-17 years (inclusive)
• have moderate tic severity or greater as evidenced by a YGTSS Total Tic Score greater than 13 (>9 for youth with motor or vocal tics only)
• have not received more than 4 previous sessions of HRT
• be fluent in English.
• Medication free or on a stable dose of psychiatric medication for 8 weeks prior to enrollment.

Exclusion criteria for youth with TS:

• An inability to complete rating scales
• Attend study visits.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Habit Reversal Training

Experimental group

Description:

Habit Reversal Training (HRT) is a multi-component evidence-based treatment for tics. It will be delivered over 4 two-hour sessions in an intensive format.

Treatment:

Behavioral: Habit Reversal Training