Extracellular Fluid in Resistant Hypertension

St George's, University of London

Status

Terminated

Conditions

Hypertension

Treatments

Drug: Cardura XL 4 mg bd

Drug: Furosemide 40 mg bd

Drug: Amiloride 5 mg bd

Study type

Interventional

Funder types

Other

Identifiers

NCT00141596

LREC 03.0001

Details and patient eligibility

About

The optimal treatment of drug resistant (defined as BP> 140/85 despite three anti-hypertensive drugs including a diuretic) is not well defined. This study aims to test the hypothesis that resistant hypertension is caused by excessive expansion of extracellular fluid volume. A secondary objective is to study which of three different antihypertensive drugs would be most useful in drug resistant hypertension.

Full description

Following recruitment subjects will have ECV measured by 51Cr-EDTA determination of GFR, with Brochner-Mortensen correction applied. Subjects then receive the following drugs, in a randomised fashion, for a period of four weeks each, with BP & ECV measurement at end of each period: doxazosin GITS (Cardura XL) 4 mg b.d.; frusemide 40 mg b.d.; amiloride 5 mg b.d.; placebo.

Enrollment

32 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria