Extracorporeal Membrane Oxygenation Evaluated by Transcranial Doppler. (ECMO-DTC)

Toulouse University Hospital

Status: Unknown

Conditions: Extracorporeal Membrane Oxygenation Complication

Treatments: Other: Examination : a TCD and Trans-Thoracic Echocardiography

Study type: Interventional

Funder types: Other

Identifiers

NCT03457090

2018-A00320-55 (Other Identifier)

RC31/18/0042

Details and patient eligibility

About

To determine how venoarterial extracorporeal membrane oxygenation (ECMO) affects cerebral blood flow velocity (CBFV) measured by transcranial doppler (TCD), to determine whether specific changes in cerebral blood flow velocity may be associated with neurologic injury and to determine modifications of CBFV after withdrawal of ECMO.

Full description

Venoarterial Extracorporeal membrane oxygenation (ECMO) is used in adult with refractory cardiac failure as a life-saving measure. Adults treated with ECMO survived to hospital discharge in 21,8% to 65,4% of cases. Neurologic complications such as intracranial hemorrhage, anoxia and ischemia are major causes of death and long-term disability in ECMO patients (7% to 14%). Current neurological monitoring techniques are insufficient to predict which critically ill patient receiving ECMO therapy will suffer from neurologic injury. Even after a clinical suspicion of neurologic injury, diagnosis can be difficult. TCD is commonly used to monitor the CBFV of traumatic brain injury. There are no reports that evaluate CBFV of patients requiring ECMO therapy. Patient will have to do both echocardiography and TCD to evaluate cardiac output and CBFV. We will repeat these dopplers every 24 hours until ECMO withdrawal and one day after explantation.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patient who receiving ECMO therapy

Exclusion criteria

• cervico-encephalic vasculopathy
• lacked an acoustic window allowing for adequate TCD examination
• stroke in medical past.

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Patient treated with ECMO

Experimental group

Description:

Patient treated with ECMO will have Examination : a TCD and Trans-Thoracic Echocardiography (TTE)

Treatment:

Other: Examination : a TCD and Trans-Thoracic Echocardiography