Extracorporeal Shock-Wave Therapy (ESWT) vs Phytotherapy vs Combined in Treatment of Chronic Prostatitis

Ain Shams University

Status: Not yet enrolling

Conditions: Chronic Prostatitis (CP)

Treatments: Drug: Phytotherapy that contains powder extract of (saw palmetto , tomato , uva ursi , pygeum and pumpkin; Device: ESWT

Study type: Interventional

Funder types: Other

Identifiers

NCT07066735

FMASU RSS/2025

Details and patient eligibility

About

to compare the efficacy and safety of ESWT combined with phytotherapy, ESWT alone and phytotherapy alone in treatment of chronic prostatitis.

Full description

In this study the investigators will conduct a Prospective randomized clinical trial, patients will be randomized to 3 groups where they will use use radial waves device (INTELECT RPW SHOCKWAVE) By Chattanooga for ESWT. Another group will receive Phytothyrapy that will be capsules containing powder extract of saw palmetto , tomato , uvaursi , pygeum and pumpkin. while the last group will receive both.

Enrollment: 90 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Perineal or pelvic pain or discomfort of at least 3 months
• NIH-CPSI total score greater than 15,
• Negative semen cultures for bacteria.

Exclusion criteria

• Evidence of bacteria in seminal culture tests,
• Urinary stones,
• Uncontrolled coagulopathy,
• Chronic bacterial prostatitis,
• Bladder and prostate cancer,
• Medications that could affect lower urinary tract function during the last month
• Serum prostate-specific antigen levels (PSA) more than 4 ng/mL
• History of prostate surgery or radiotherapy
• Perineal anatomical abnormalities
• Neurological abnormalities.
• Previous extensive pelvic injuries

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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90 participants in 3 patient groups

Group A ESWT and Phytotherapy

Experimental group

Description:

First group will undergo ( ESWT -Transperineal- once a week for 8 consecutive weeks with a protocol of 3000 pulses each; pressure: 1.8-2.0 bar and a frequency of 10 Hertz (Hz) (Zhang et al . 2018) combined with Phytotherapy that contains powder extract of (saw palmetto , tomato , uva ursi , pygeum , pumpkin ) 1capsule twice daily.

Treatment:

Device: ESWT

Drug: Phytotherapy that contains powder extract of (saw palmetto , tomato , uva ursi , pygeum and pumpkin

Group B: ESWT alone

Experimental group

Description:

Transperineal- once a week for 8 consecutive weeks with a protocol of 3000 pulses each; pressure: 1.8-2.0 bar and a frequency of 10 Hertz (Hz)

Treatment:

Device: ESWT

Group 3: Phytotherapy alone

Active Comparator group

Description:

Phytotherapy that contains powder extract of (saw palmetto , tomato , uva ursi , pygeum , pumpkin ) 1capsule twice daily

Treatment:

Drug: Phytotherapy that contains powder extract of (saw palmetto , tomato , uva ursi , pygeum and pumpkin