Extramedullary Acute Myeloid Leukemia (eAML): Retrospective Single Center Cohort Study, Clinicopathological, Molecular Analysis and Survival Outcomes

King Hussein Cancer Center

Status: Completed

Conditions: Acute Myeloid Leukemia

Treatments: Other: retrospective data analysis

Study type: Observational

Funder types: Other

Identifiers

NCT05057299

20 KHCC 169

Details and patient eligibility

About

Patients with extramedullary leukemia were identified over 10 years (January 2003 to September 2019). Clinicopathological,genetic-molecular features were identified and survival outcomes were studied and analyzed.

Full description

We retrospectively collected patients demographics ,including clinicopathological and genetic-molecular parameters in patients with extramedullary leukemia between January 2003 till September 2019 from King Hussein cancer center(KHCC) electronic medical records. All potential prognostic factors were identified and compared with worldwide data published previously. Treatment and survival outcomes were studies and analyzed.

Primary endpoint : Overall survival (OS).

Secondary endpoint :

• Progression Free Survival (PFS).
• incidence of extramedullary leukemia.

Enrollment: 32 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult subjects aged ≥18 year and up to 75 years
• Male and females.
• Initially diagnosed and treated with extramedullary leukemia at KHCC and followed till last encounter.
• Patients, who underwent an allogeneic stem cell transplant.
• Period January 2003-September 2019

Exclusion criteria

• Pediatric patients <18 year of age
• Patients, who lost their follow up within study period.

Trial design

32 participants in 1 patient group

Patients with extramedullary leukemia(eAML) with myeloid neoplasms

Treatment:

Other: retrospective data analysis