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Extreme Lipids Repository

The University of Texas System (UT) logo

The University of Texas System (UT)

Status

Enrolling

Conditions

Lipoprotein Disorder

Treatments

Other: No intervention is involved in this study

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT04156997
STU-2018-0429
1K24HL146838-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This is a prospective, observational study to establish a repository of samples from patients with extreme lipid phenotypes including but not limited to hyperlipidemia, dyslipidemia, hyperlipoproteinemia, extreme low/high HDL levels and deranged lipoprotein metabolism. The investigators plan to conduct sophisticated composition and functional analyses as well as genetic analysis to better understand the determinants of extreme lipid derangements.

Full description

Participants will be recruited from clinical encounters within the University of Texas (UT) Southwestern Medical Center and Parkland Hospital by screening the Electronic Medical Record (EMR) for those with lipid labs and values that satisfy criteria for extreme values. Identified participants will be recruited to provide health information via survey, permission to extract clinical information from the EMR, and blood collection for future analyses. Measurements will span direct measurement of circulating species, genetic analyses, and analysis of circulating cells. The blood specimens will be stored for future studies and collaborations and thus, will constitute a blood-based repository. All study procedures are experimental but do not involve an actual intervention.

Enrollment

250 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • adult patients (age 18 years or older) diagnosed with any lipid or metabolic disorder including hyperlipidemia, dyslipidemia, hyperlipoproteinemia, low HDL levels and deranged lipoprotein metabolism

Exclusion criteria

  • Anyone under 18 years of age will be excluded from the study.

Trial design

250 participants in 2 patient groups

Patients with extreme lipid phenotypes
Description:
Adult patients (age 18 years or older) diagnosed with any lipid or metabolic disorder including hyperlipidemia, dyslipidemia, hyperlipoproteinemia, low HDL levels and deranged lipoprotein metabolism
Treatment:
Other: No intervention is involved in this study
Healthy volunteers
Description:
Healthy adult volunteers with normal lipid metabolism will be recruited for the purpose of comparison
Treatment:
Other: No intervention is involved in this study

Trial contacts and locations

2

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Central trial contact

Shailesh Jaiswal

Data sourced from clinicaltrials.gov

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