Eye Movements Recording Using a Smartphone: Comparison to Standard Video-oculography in Patients With Multiple Sclerosis

Association de Recherche Bibliographique pour les Neurosciences

Status: Completed

Conditions: Multiple Sclerosis

Treatments: Other: Eye-Tracker®T2 + e-VOG; Other: e-VOG + Eye-Tracker®T2

Study type: Observational

Funder types: Other

Identifiers

NCT04702763

e-VOG

Details and patient eligibility

About

This study aims to compare measurements obtained through the e-VOG application (mobile application, usable on mobile phones or tablets, to measure eye movements) with measurements from the standard video-oculography device (Eye-Tracker®T2), in patient with Multiple Sclerosis.

Full description

Based on literature, investigators hypothesize that it would be relevant to focus more broadly on subclinical abnormalities of oculomotricity in multiple sclerosis (MS). However, the difficulty of accessing video-oculography platforms (or eye-tracking devices) is probably one of the main limitations to performing this type of assessment.

To respond this problem, the "Resources and Skills Center-Multiple Sclerosis" (CRC SEP) team at the Nice University Hospital Center (France) has developed a mobile application (named e-VOG), usable on mobile phones or tablets, to measure eye movements. e-VOG reproduces the classic paradigms of video-oculography to collect data similar to standard video-oculography recording (saccade latency and speed, anti-saccade error rate, presence of fixation abnormalities).

e-VOG will not replace standard video-oculography platforms, because its technical characteristics are not as high. But investigators hypothesize that this application could constitute a screening tool for subclinical oculomotor abnormalities, usable by neurologists in consultation, directly on their mobile, which would make it possible to select a smaller population of patients in whom a further exploration by standard video-oculography would be indicated.

Memory Center of the Rainier III Gerontologic Center (Princess Grace Hospital - Monaco) is equipped with a standard video-oculography device, also named eye-tracking device (Eye-Tracker®T2), which records eye movements at a high frequency and measures saccades parameters (latency, speed, amplitudes etc...).

This study is a collaborative study between the Center Rainier III team and the CRC SEP team in Nice. Its objective will be to compare measurements obtained through the e-VOG application with measurements from the standard video-oculography device.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or Female.
• 18 years old and above.
• referred by a neurologist to perform a video-oculography (Eye-Tracking) examination as part of routine care.
• with Multiple Sclerosis (defined according to McDonald's 2017 criteria).
• covered by a health insurance system
• volunteer, able to give free, informed and written consent.

Exclusion criteria

• General anaesthesia within 3 months.
• Neurological, ophthalmological or general pathology preventing the realization of a video-oculography examination.
• Oculomotor abnormality detectable on clinical examination by the neurologist prescribing the standard video-oculography examination.

Trial design

30 participants in 2 patient groups

Multiple Sclerosis (Eye-Tracker®T2 + e-VOG)

Description:

Multiple Sclerosis subjects who first perform standard video-oculography assessment, followed by e-VOG digital assessment.

Treatment:

Other: Eye-Tracker®T2 + e-VOG

Multiple Sclerosis (e-VOG + Eye-Tracker®T2)

Description:

Multiple Sclerosis subjects who first perform e-VOG digital assessment, followed by the standard video-oculography assessment.

Treatment:

Other: e-VOG + Eye-Tracker®T2