EyeConic: Qualification for Cone-Optogenetics

Institute of Molecular and Clinical Ophthalmology Basel

Status

Enrolling

Conditions

Retinal Dystrophies

Treatments

Diagnostic Test: Optical coherence tomography (OCT)

Study type

Observational

Funder types

Other

Identifiers

NCT05294978

IOB_EyeConic_2021

Details and patient eligibility

About

This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.

Full description

In a subset of patients with inherited retinal dystrophies (IRDs), cones lose their light-sensitive outer segments but remain alive in a dormant stage. This creates an opportunity to resensitize them through targeted optogenetic tools. However, the true proportion of low vision patients harboring dormant, non-functional cones, is currently unknown. The worldwide multicenter retrospective study (EyeConic) aims to estimate the proportion of low vision patients with remaining cone cell bodies for the first time.

Enrollment

1,000 estimated patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria (patients):

Diagnosis of generalized IRD
Low vision as defined as visual acuity worse or equal to 0.05 (or 20/400) in the study eye
Availability of macular optical coherence tomography (OCT)

Inclusion Criteria (controls):

Normal ophthalmic findings
Availability of macular optical coherence tomography (OCT)

Exclusion Criteria (all):

Other eye diseases with a significant effect on vision or retinal structure
Extraocular disease affecting retinal structure such as neurodegenerative diseases