f Adding Ketamine to Propofol For Drug-induced Sleep Endoscopy in Adult Patients With Obstructive Sleep Apnea

Zagazig University

Status and phase: Unknown; Phase 4

Conditions: Sleep Apnea Syndromes

Treatments: Drug: propofol; Drug: Ketamine + propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT04452383

Sedation in DISE

Details and patient eligibility

About

The investigator compared the sedative effects of propofol alone and ketamine added to propofol in drug induced sleep endoscopy

Full description

Propofol and ketamineare commonly used intravenous anesthetic drug used for procedural sedation.

The investigator compared the effect of propofol and propofol ketamine in patients undergoing drug induced sleep endoscopy.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Age > 18 years old.
• American society of anesthesiologists (ASA) physical status I or II. I / II

Exclusion Criteria:

• patient refusal
• American society of anesthesiologists (ASA) physical status > III
• known or suspected allergy to the studied drugs or its components, allergy to eggs or soy beans
• morbid obesity
• patients with moderate to severe chronic obstructive pulmonary disease or uncontrolled asthma, congestive e heart failure ,seizures ,or cerebrovascular disease
• pregnancy

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

30 participants in 2 patient groups

propofol (P)

Active Comparator group

Description:

patients will receive only propofol intravenous for sedation

Treatment:

Drug: propofol

propofol ketamine (pk)

Active Comparator group

Description:

patients will receive ketamine in addition to propofol intravenous for sedation

Treatment:

Drug: Ketamine + propofol