Facilitating Motor Skill Learning in Parkinson's Disease II (FaST-PD II)

University of Erlangen-Nürnberg

Status: Completed

Conditions: Parkinson Disease

Treatments: Behavioral: motor learning; Behavioral: rest; Behavioral: aerobic exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03886090

DSN-2018

Details and patient eligibility

About

The study is designed to assess the effects of cardiovascular (aerobic) exercise on motor skill learning in Parkinson patients. Specifically, the investigators examine whether a single bout of moderate-intense aerobic exercise, performed immediately following motor skill practice, facilitates motor memory consolidation. In this experimental trial, participants will be randomly allocated to either an intervention group (motor skill practice + aerobic exercise) or control group (motor skill practice + seated rest).

Full description

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by motor control impairments, such as gait disturbances and postural instability. Beneficial effects of exercise are attributed to mechanisms of neuroplasticity, and task-specific motor training (repeated practice of a skill) is consequently considered to be a motor learning process. Importantly, the formation (acquisition) and consolidation of motor memories is impaired in PD compared to healthy individuals of similar age.

Thus, it is crucial to identify strategies to enhance motor learning in people with PD. Recent studies have accumulated evidence to show that acute (single bouts of) cardiovascular exercise can facilitate motor skill learning. However, this evidence is mainly derived from studying healthy individuals. In a first study including PD patients, we recently found improved motor memory consolidation, but not skill acquisition, when practice was preceded by a single bout of cardiovascular exercise.

These results suggest that acute exercise may enhance motor memory formation processes, but could potentially interfere with motor skill acquisition when performed prior to practice. Consequently, the present study investigates whether performing a single bout of cardiovascular exercise immediately following skill practice will enhance motor memory consolidation without affecting skill acquisition in PD.

In an experimental trial, participants will be randomly allocated to one of two groups. Both groups will practice balancing on a stability platform (motor learning task). The experimental group will additionally perform a bout of aerobic exercise (cycle ergometer) immediately following motor practice, while the control group will rest. Subsequently, motor skill retention will be tested after 24 hour and seven-days.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parkinson's disease stage 1-3 on Hoehn & Yahr scale
• Ability to stand unaided and walk without an assistive device
• Stable medication during the study period
• Unfamiliar to the motor learning task

Exclusion criteria

• On-off and wearing-off phenomena
• Unstable medical or psychiatric illness
• Clinically relevant cardiovascular or orthopaedic disease
• Severe polyneuropathy
• Cognitive impairment
• Smoking > 10 cigarettes/day
• Caffeine > 6 cups of coffee/day
• Alcohol > 50 g (two glasses)/day

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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18 participants in 2 patient groups

motor skill practice + aerobic exercise

Experimental group

Description:

acute bout of aerobic exercise following motor skill practice

Treatment:

Behavioral: motor learning

Behavioral: aerobic exercise

motor skill practice + rest

Active Comparator group

Description:

seated rest following motor skill practice

Treatment:

Behavioral: motor learning

Behavioral: rest