Factor V Leiden Mutation and Implantation Failure

University of Pennsylvania

Status: Completed

Conditions: Infertility

Treatments: Procedure: Test for Factor V Leiden gene mutation

Study type: Observational

Funder types: Other

Identifiers

NCT00194350

704111

Details and patient eligibility

About

The purpose of this study is to determine whether inherited thrombophilias (tendency toward blood clotting) increase the risk of failure of the embryo to implant in IVF. The specific condition to be studied is the presence or absence of the Leiden mutation of the Factor V gene.

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women undergoing in-vitro fertilization with successful ovarian hyperstimulation, oocyte retrieval, and fertilization
• Transfer of at least 2 fresh embryos of Grade 2 (preembryo with blastomeres of equal size and <=10% cytoplasmic fragmentation) or better

Exclusion criteria

• Infertility due to uterine anatomic defect
• Current use of anticoagulant medication, such as heparin or aspirin
• Known presence of any other condition associated with increased risk of thrombosis