Factor XIII Activity in Gastrointestinal Bleedings

Medical University of Graz

Status: Completed

Conditions: Gastro Intestinal Bleeding

Treatments: Drug: Factor XIII Injection

Study type: Observational

Funder types: Other

Identifiers

NCT05933135

EK 33-123 ex 20/21

Details and patient eligibility

About

The aim of this retrospective study is to investigate the relationship between factor XIII activity and the outcome of gastrointestinal bleedings. Since factor XIII is of great importance in haemostasis and plays a key role in stabilizing the fibrin clot, it can be assumed that a deficiency of factor XIII leads to an unfavorable course of gastrointestinal bleedings. Our hypothesis is that early detection of such a deficiency can prevent a more severe course and that substitution of factor XIII contributes to faster cessation of bleeding, improves patient outcome and reduces the number of red cell concentrates required.

Enrollment: 97 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age over 18 years
• Confirmed diagnosis of gastrointestinal bleeding
• Assessment of factor XIII activity during the gastrointestinal bleeding episode

Exclusion criteria

• Age under 18 years
• Diagnosis of hemophilia A or B or other congenital coagulation disorders

Trial design

97 participants in 2 patient groups

Normal factor XIII acitivity

Description:

Patients with GI bleeding and normal factor XIII activity

Reduced factor XIII activity

Description:

Patients with GI bleeding and reduced factor XIII activity

Treatment:

Drug: Factor XIII Injection