Factor XIII and Pulmonary Embolism in Neurosurgical Patients

Ludwig Maximilian University of Munich

Status: Unknown

Conditions: Pulmonary Embolism; Vascular Lesion; Brain Tumor; Factor XIII Deficiency

Study type: Observational

Funder types: Other

Identifiers

NCT01106937

SG-1

Details and patient eligibility

About

Two studies (Gerlach et al. 2000; Gerlach et al. 2002) described the impact of factor XIII on the risk of prospective hemorrhage for patients undergoing craniotomy. Since then, factor XIII is measured and substituted in various centers. Few reports support the idea of factor XIII being involved in the formation of deep venous thrombosis and pulmonary embolism. In this prospective observational study, patients undergoing craniotomy for brain tumors or vascular lesions are investigated concerning the incidence of postoperative pulmonary embolism in respect of possible risk factors (factor XIII activity levels, standard coagulation parameters, tumor entity, blood loss).

Enrollment: 130 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• preoperatively low Factor XIII activity
• neurosurgical procedure (craniotomy)
• substitution of Factor XIII
• postoperative occurence of pulmonary embolism

Exclusion Criteria:

Trial design

130 participants in 1 patient group

Patients with low Factor XIII

Description:

Postoperative occurence of pulmonary embolism in patients scheduled to undergo a neurosurgical procedure with laboratory-confirmed low levels of Factor XIII