Factors Affecting the Results of Treatment of Patients With Colorectal Cancer

Immanuel Kant Baltic Federal University

Status: Enrolling

Conditions: Rectal Adenocarcinoma; Colorectal Adenocarcinoma; Colorectal Neoplasms Malignant; Colon Cancer; Rectal Cancer; Colorectal Cancer

Treatments: Procedure: Left hemicolectomy; Procedure: Low anterior resection of the rectum; Procedure: Total Colectomy; Procedure: Anterior resection of the rectum; Procedure: Abdominoperineal resection; Procedure: Right hemicolectomy; Procedure: Sigmoid colon resection

Study type: Observational

Funder types: Other

Identifiers

NCT06050447

5995465480

Details and patient eligibility

About

The study attempts to quantify the relative risks for mortality, anastomotic leakage and other early and late postoperative complications, recurrence rate, cancer-specific survival, recurrence-free survival after colorectal surgery for patients with colorectal cancer depending on the localization of the tumor.

Enrollment: 1,200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically proven primary adenocarcinoma of bowel;
• All patients who have indications for surgical treatment of colorectal cancer based on the decision of the oncological council;
• Signed informed consent with agreement to attend all study visits;

Exclusion criteria

• Unresectable tumor or contradictions to surgery;
• Indications for chemotherapy or radiation therapy prior to surgery;
• Patient withdrawal from the trial or loss of follow-up;
• Emergent operation;
• Pregnancy.

Trial design

1,200 participants in 4 patient groups

Patients with right-sided colon cancer

Description:

Tumors located anywhere from the cecum to the proximal transverse colon.

Treatment:

Procedure: Right hemicolectomy

Patients with left-sided colon cancer

Description:

Tumors located anywhere from the distal transverse colon to the rectosigmoid junction

Treatment:

Procedure: Left hemicolectomy

Procedure: Sigmoid colon resection

Patients with rectal cancer

Description:

Tumors located in rectosigmoid junction and in the rectum with/without the external sphincter or the levator muscles invasion

Treatment:

Procedure: Anterior resection of the rectum

Procedure: Low anterior resection of the rectum

Procedure: Abdominoperineal resection

Patients with right- and left-sided colon cancer (primary multiple cancer)

Description:

Patients with primary multiple cancer tumors

Treatment:

Procedure: Total Colectomy