Factors and Prognostic Significance of Impaired Exercise Tolerance in Women Over 40 With Arterial Hypertension

Polish Mother Memorial Hospital Research Institute

Status

Completed

Conditions

Arterial Hypertension

Heart Failure

Treatments

Diagnostic Test: Diagnostic tests

Study type

Interventional

Funder types

Other

Identifiers

NCT04802369

PMMHRI-BCO.71/2020

Details and patient eligibility

About

The subject of the study is evaluation of factors affecting to exercise intolerance in spiroergometry in women over 40 years of age with hypertension and association and relationship between the parameters of physical performance and prognosis in this group of patients.

Full description

The 185 women over 40 years of age hospitalized for arterial hypertension in the Department of Cardiology will be included in the study, including: the study group who demonstrated maximal oxygen consumption measured during incremental exercise indexed per kilogram - VO2max<17 ml/kg/min and a second group who presented VO2max>17 ml/min/kg.Selected prognostic factors will be analyzed, among others: demographic data of the patient, physical examination, symptoms, etiology and history of arterial hypertension, co-morbidities, results of selected laboratory tests, selected electrocardiographic and echocardiographic data, patient's cooperation with the doctor, treatment applied, parameters in the spiroergometric study, non-invasive assessment for central arterial pressure waveform analysis and body mass analysis.

Enrollment

185 patients

Sex

Female

Ages

40 to 99 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age equal to or older than 40 years
Arterial hypertension (HA) diagnosed according to the 2018 European Society of Cardiology (ESC) guidelines of HA [1]
Current HA hospitalization

Exclusion criteria

Severe hypertension
Diagnosis of heart failure or typical symptomatic heart failure
Left ventricular ejection fraction (LVEF) <50%
Documented: hyperandrogenism, hyperestrogenism, insulin resistance, premature ovarian failure, polycystic ovary syndrome
Past myocardial infarction
Diagnosis of cardiomyopathy (hypertrophic, dilated, restrictive, peripartum, arrhythmogenic)
Lysosomal storage disorders
Stroke, transient ischemic attack, Intracerebral hemorrhage in medical history
Severe hyper- and hypothyroidism
Pregnancy and lactation
Chronic kidney disease (IV, V stadium according to National Kidney Foundation) and dialysis treatment
Documented neoplastic process
The patient's inability to cooperate and/or provide informed consent to participate in a research
Alcohol and drug abuse
Active autoimmune disease
Treatment using immunosuppressants, cytostatic drugs, glucocorticosteroids, or antiretroviral drugs
A history of bone marrow transplant or other organ transplant, treatment with blood products within the last 6 months
Active systemic infection
Hepatitis B virus (HBV), hepatitis C virus (HCV) or human immunodeficiency virus (HIV) carrier or positive for hepatitis B surface antigen (HBSAg) or antibodies to HCV
Surgery or serious injury within the last month
Patients who did not express their informed consent to participate in the study