Factors Associated With Complications of Cervical Necrotizing Fasciitis

Civil Hospices of Lyon

Status: Unknown

Conditions: Cervical Necrotizing Fasciitis

Study type: Observational

Funder types: Other

Identifiers

NCT02847234

69HCL16_0500

Details and patient eligibility

About

Cervical necrotizing fasciitis (CNF) is a rare but severe complication of pharyngeal or dental infections. The infection can rapidly descend into the mediastinum and lead to a life-threatening prognosis. Treatment consists of a multidisciplinary approach in intensive care with radiologist and with early and repeated surgical debridement. Anti-inflammatory drugs have been incriminated by authors in the development of necrotizing fasciitis. Recently, a single-center study demonstrated that pharyngeal source of CNF and oral glucocorticoid intake before admission was associated with the occurrence of mediastinitis.

The aim of the study is to assess the incidence and factors associated with CNF complications, in particular mediastinitis. Secondary outcome is to describe patient characteristics, medical and surgical management.

Methods: A retrospective, observational, non-interventional multicentre study is conducted in nine intensive care units in France from January 2005 to December 2016.

Enrollment: 350 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient admitted in ICU for management of cervical necrotizing fasciitis between 2005 and 2016.

Exclusion criteria

• Patients admitted in ICU for management of cervical abscess without cervical necrotizing fasciitis
• Age < 18 years