Factors Associated With Interdialytic Blood Pressure Variability in Maintenance Hemodialysis Patients

Capital Medical University

Status: Unknown

Conditions: Kidney Failure, Chronic

Study type: Observational

Funder types: Other

Identifiers

NCT01674660

19860805 (Registry Identifier)

BeijingCYH

Details and patient eligibility

About

The purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability.

Full description

Hemodialysis patients experience higher rates of cardiovascular morbidity and mortality than the general population and many populations with other chronic diseases. This exceptional risk is explained in part by known risk factors such as diabetes, hypertension, and other uremia-related factors, including vascular calcification and stiffness, autonomic dysfunction, and a high burden of circulating inflammatory mediators. However, additional unidentified risk factors also likely contribute to the disproportionately high prevalence of cardiovascular morbidity in hemodialysis patients. Blood pressure variability may represent one plausible cardiovascular risk factor. Data from nonuremic human populations show an association between greater blood pressure variability and cardiovascular events,nonfatal cardiovascular events,stroke,and increased left ventricular mass. There has been comparatively little work examining the causes and effects of blood pressure variability in hemodialysis populations. So the purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability.

Enrollment: 100 estimated patients

Sex: All

Ages: 24 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• age 18 years or older
• receipt of thrice-weekly in-center hemodialysis
• no anticipation of imminent(<6 months)living related kidney transplant
• not transfer of care to a nonparticipating facility
• no dialytic modality change
• free of vascular, infectious, or bleeding complication within 1 month Exclusion Criteria:
• who missed >2 hemodialysis treatments over 1 month
• abused drugs
• severe anemia，malnutrition，chronic atrial fibrillation
• body mass index of 40 >kg/m2

Trial design

100 participants in 3 patient groups

volume status

Description:

volume status:group1 over volume status,group2 normal volume status,group3 low volume status

night blood pressure

Description:

night blood pressure：group1 nondipper,group2 dipper,group3 extreme dipper,group4 riser

interdialysis weight gain

Description:

interdialysis weight gain:group1 \>5% dry weight,group2 \<5% dry weight