Factors Associated With Post-induction Hypotension in iNPH Patient Undergoing VP and LP Shunt

Mahidol University

Status: Completed

Conditions: The iNPH Patients Scheduled for VP or LP Shunt Procedures

Treatments: Drug: Ehedrine Norepineprine

Study type: Observational

Funder types: Other

Identifiers

NCT05183061

961/2563(IRB4)

Details and patient eligibility

About

This study is a retrospective work involving the review of patients who were scheduled for VP or LP shunt in Siriraj Hospital, Mahidol University, Thailand. The sample size calculation was based on the rule of thumbs of the logistic regression comprising 18 risk factors. The incidence of post-induction hypotension according to our institution's pilot study November 2019-January 2020) was 47%. With 10% addition for missing data and other possible reasons, the sample size was 426. The primary objective of the study is to report the factors associated with post-induction hypotension in iNPH patients undergoing VP or LP shunt procedures. Our secondary objective is to determine the incidence of post-induction hypotension in these patients.

Enrollment: 426 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Elective cases of iNPH scheduled for VP and LP shunt
• Patients aged > 18 years old

Exclusion criteria

• Emergency cases

Trial design

426 participants in 2 patient groups

Hypotensive group

Description:

Hypotenson is defined as systolic blood pressure (SBP) \< 80 mmHg or a drop more than 20% from baseline SBP for longer than 10 minutes or a drop that requires treatment either vasopressor or inotropic drugs.

Treatment:

Drug: Ehedrine Norepineprine

Non-hypotensive group

Description:

The pateints who did not develop hypotensive episodes as aforementioned.