Factors That Influence Blood Vessel Regulation During Exercise in Humans

University of Guelph

Status: Completed

Conditions: Dietary Exposure; Ischemic Preconditioning

Treatments: Dietary Supplement: Low fat meal; Procedure: Ischemic preconditioning control; Dietary Supplement: High fat meal; Procedure: Ischemic preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT04887610

20-11-008

Details and patient eligibility

About

This study will examine two separate interventions: 1) the effects of ischemic preconditioning or 2) a high fat meal on the capacity of the brachial artery to overcome sympathetic activation and dilate during exercise (also known as functional sympatholysis). Participants will be asked to complete rhythmic handgrip exercise with and without the application of -20 mmHg lower body negative pressure to increase sympathetic activation. Doppler ultrasound will be used to continuously measure brachial artery blood flow. Participants will complete the handgrip exercise and lower body negative pressure before and after the applications of each interventions. Participants may elect to only complete one intervention rather than complete both protocols. Intervention one is active or control ischemic preconditioning. Intervention two is high or low fat meals.

Enrollment: 20 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years or older
• Healthy

Exclusion criteria

• History of smoking (tobacco or cannabis), defined as any smoking within the past 3 months
• Diagnosed cardiovascular or metabolic disease(s)
• Recent musculoskeletal injury handgrip exercise
• Prescription of chronic medications other than oral contraceptives
• History of hypertension or presence of arrhythmia

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 4 patient groups, including a placebo group

Ischemic preconditioning control

Sham Comparator group

Treatment:

Procedure: Ischemic preconditioning control

Ischemic preconditioning

Active Comparator group

Treatment:

Procedure: Ischemic preconditioning

High fat meal

Active Comparator group

Treatment:

Dietary Supplement: Low fat meal

Low fat meal

Placebo Comparator group

Treatment:

Dietary Supplement: High fat meal