Faecal Microbiota Analysis in Neurotypical and Autism Syndrome Disorder Siblings (FAMILY)

East Suffolk and North Essex NHS Foundation Trust

Status

Active, not recruiting

Conditions

Autism Spectrum Disorder

Autism

Treatments

Other: Stool sample

Study type

Observational

Funder types

Other

Identifiers

NCT05794620

22/045

Details and patient eligibility

About

This study aims to accurately characterise the gut microbiota composition of faeces of children with ASD and compare it with the gut microbiota composition of their neurotypical siblings. In addition it aims to also characterise the metagenome and metabolome of the faeces of both ASD and neurotypical siblings.

Enrollment

20 patients

Sex

All

Ages

3 to 10 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Children of both sexes who are diagnosed with ASD and under the care of ESNEFT who have a neurotypical sibling (either full or half sibling), who share their living environment. This is due to the study requiring stool samples that are from siblings, to control for genes and environment where possible.
Aged 3 years to 10 years old (at time of consent)
Parent/guardian able to consent to participate
Parent/guardian able to complete required surveys (or with accommodated adjustments)

Exclusion criteria

Use of antibiotics in the previous 4 weeks
Not under the care of ESNEFT
Children <3 years old and >10 years old
Children that don't have half or full siblings
Parent/guardian unable to provide informed consent or complete surveys, despite reasonable adjustments being implemented