Familial Analysis of Keratoconus Risk (AFRIK)

University Hospital of Bordeaux

Status: Completed

Conditions: Keratoconus

Treatments: Other: genetic

Study type: Observational

Funder types: Other

Identifiers

NCT02812563

CHUBX2013/03

Details and patient eligibility

About

The principal objective of this study is to evaluate the frequency of KC inside family of patients with confirmed KC.

It's a familial, epidemiological, prospective, single-center study.

Full description

Keratoconus is a common bilateral progressive corneal ectatic disease causing visual impairment by inducing irregular astigmatism and corneal opacities. This disorder typically begins during teenage years, progresses until the age of 30 to 40 years and, in severe forms, may need a corneal transplantation.

Currently, keratoconus has not known etiopathogenesis, and it is difficult to detect subclinical forms.

Several risk factors seem to be implied, environmental and genetic : the risk of keratoconus in case of familial history of keratoconus isn't well known at that time, but seems to be important to consider to promote screening and follow up of patient with a familial history of keratoconus (KC).

Enrollment: 95 patients

Sex: All

Ages: 7+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Case :

• patient carrier of keratoconus
• more than 7 years
• patient who didn't expressed opposition as for computerization and use of data concerning him

Family of case

• to have a first degree family member (father, mother, brother, sister, child) carrier of keratoconus
• more than 7 years
• patient who didn't expressed opposition as for computerization and use of data concerning him

Exclusion criteria

• ocular pathology or antecedent of modification of cornea (surgery, traumatism, ocular hypertension, keratitis) which could interfere with topographical analysis
• wearing of rigid contact lens for 15 days before exams, or flexible lens for 5 days before exams