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Familial B-cell Lymphoproliferative Disorders (Familial_LPD)

U

University of Haifa

Status

Not yet enrolling

Conditions

Monoclonal B-Cell Lymphocytosis
Chronic Lymphocytic Leukemia
Premalignant
Lymphoproliferative Disorders

Treatments

Other: No intervention

Study type

Observational

Funder types

Other

Identifiers

NCT05718986
FamilialLPD

Details and patient eligibility

About

This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of familial LPD, and various clinical outcomes for these families in a multiethnic population of Jews and Arabs in Israel.

Enrollment

1,000 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Patient inclusion criteria:

Patients must have LPD and must have a family history of LPD. LPD patients who signed an informed consent to participate in the study.

Criteria for the inclusion of relatives of patients:

Relatives must be related by blood to LPD patients or unrelated (for control group).

Relatives who signed an informed consent to participate in the study.

Exclusion criteria

  • Pregnant women, special populations and those lacking judgment will not be included

Trial design

1,000 participants in 15 patient groups

Bnai Zion Medical Center
Description:
Bnai Zion Medical Center
Treatment:
Other: No intervention
Tel Aviv Sourasky Medical Center - Ichilov Hospital
Description:
Tel Aviv Sourasky Medical Center - Ichilov Hospital
Treatment:
Other: No intervention
Galil Medical Center
Description:
Galil Medical Center
Treatment:
Other: No intervention
Ziv Medical Center
Description:
Ziv Medical Center
Treatment:
Other: No intervention
Emek Medical Center
Description:
Emek Medical Center
Treatment:
Other: No intervention
Beilinson Hospital
Description:
Beilinson Hospital
Treatment:
Other: No intervention
Meir Medical Center
Description:
Meir Medical Center
Treatment:
Other: No intervention
Kaplan Medical Center
Description:
Kaplan Medical Center
Treatment:
Other: No intervention
Sheba Medical Center
Description:
Sheba Medical Center
Treatment:
Other: No intervention
Rambam Medical Center
Description:
Rambam Medical Center
Treatment:
Other: No intervention
Shaare Zdek Medical Center
Description:
Shaare Zdek Medical Center
Treatment:
Other: No intervention
Hadassah Medical Center
Description:
Hadassah Medical Center
Treatment:
Other: No intervention
Shamir Medical Center (Assaf Harofeh)
Description:
Shamir Medical Center (Assaf Harofeh)
Treatment:
Other: No intervention
Soroka Medical Center
Description:
Soroka Medical Center
Treatment:
Other: No intervention
Assuta Ashdod Hospital
Description:
Assuta Ashdod Hospital
Treatment:
Other: No intervention

Trial contacts and locations

0

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Central trial contact

Geffen Kleinstern, PhD; Tamar Tadmor, MD

Data sourced from clinicaltrials.gov

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