Familial Clustering of Vitamin D Deficiency Via Shared Environment: The Korean National Health And Nutrition Examination Survey 2008-2012

Yonsei University

Status: Completed

Conditions: Vitamin D Deficiency

Study type: Observational

Funder types: Other

Identifiers

NCT03349879

2012-01EXP-01-2C

Details and patient eligibility

About

Vitamin D deficiency is a modifiable risk factor for poor bone health. Familial correlation of serum 25-hydroxyvitamin D concentration (25(OH)D) was reported in twin- or family-based studies, mostly from Caucasian parent-offspring pairs. However, data on the familial association of 25(OH)D in extended family structure and the relative contribution of genetic and shared environmental factors on serum 25(OH)D level are limited in Asian populations. In this study, the investigators aimed to assess the relative contribution of additive genetic and environmental components on serum 25(OH)D level by variance components method in a nationwide family-based cohort. Further, the investigators will evaluate the association of vitamin D status of index individual with prevalent vitamin D deficiency of each family member including spouse, offspring, sibling, and grand-offspring. Additive influences of paternal and maternal vitamin D status on offspring will be also investigated.

Full description

From the Korean National Health and Nutritional Examination Survey (KNHANES) conducted between 2008 and 2012, familial correlations for 25(OH)D will be estimated in different types of family relation pairs in 28551 subjects from 10882 families. The relative contribution of additive genetic and shared or individual environmental factors for variance of 25(OH)D level will be calculated using variance component method. Interactions between paternal and maternal vitamin D status for 25(OH)D level of offspring will be evaluated.

Enrollment: 28,551 patients

Sex: All

Ages: 10 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• KNHANES(Korean National Health and Nutrition Examination Survey) 2008-2012 participants

Exclusion criteria

• missing value on 25-hydroxyvitamin D levels
• data on another household member was unavailable
• the precise family relationship between the subjects was unclear

Trial design

28,551 participants in 3 patient groups

Vitamin D deficiency

Description:

serum 25(OH)D \< 30 nmol/L

Vitamin D insufficiency

Description:

serum 25(OH)D between 30 and 49 nmol/L

Vitamin D sufficiency

Description:

serum 25(OH)D ≥ 50 nmol/L