Families With Substance Use and Psychosis: A Pilot Study

Mass General Brigham

Status: Completed

Conditions: Alcohol; Cigarette Smoking; Substance Use; Psychosis; Bipolar Disorder; Cannabis; Schizoaffective Disorder; Nicotine Use Disorder; Alcohol Use Disorder; Tobacco Use; Mental Disorder; Schizophrenia; Family; Substance Use Disorders; Marijuana

Treatments: Behavioral: CRAFT-FT

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04284813

2020P000220

1K23DA050808-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine (video conferencing). The intervention aims to improve treatment engagement and reduce distress, and it will be delivered via telemedicine (CRAFT-FT). To assess feasibility of the intervention, family members will complete the sessions and provide feedback to refine the treatment manual. Data on client relatives with psychosis will be collected for preliminary assessment purposes. Client relatives will not complete the research study intervention.

Enrollment: 29 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages 18-70.

• Having a relative who:

  1. Is a patient with early course psychosis (DSM-5 schizophrenia, schizoaffective disorder, schizophreniform, psychosis not otherwise specified (NOS), delusional disorder, brief psychotic disorder, major depression with psychosis, and bipolar disorder with psychosis) with first onset in the past 6 years, and
  2. Uses tobacco, alcohol, or cannabis in the past 90 days and/or has no apparent immediate interest in abstinence.

• The person(s) who can best describe the client with psychosis.

• At least 4 days per month contact with the client.

• Access to a computer with internet or mobile phone with video conferencing capabilities.

• Ability to provide written informed consent.

• Speak and read English.

Exclusion criteria

• DSM-5 moderate or severe substance use disorder in the past year.
• Lifetime psychotic disorder.
• History of domestic violence with the identified patient (IP).
• Psychiatric, cognitive, or medical impairments that would interfere with the ability to follow through with the treatment plan.

Inclusion Criteria for Client Relatives:

• Ages 18-35.

• First episode psychosis (FEP) onset in the past 6 years with a DSM-5 diagnosis of affective (bipolar disorder or major depressive disorder with psychotic features) or non-affective psychosis (schizophrenia spectrum disorder).

  a. Used tobacco, alcohol, or cannabis within the past 90 days and/or has no apparent immediate interest in abstinence.

• Ability to provide written informed consent.

• Speak/read English

Exclusion Criteria:

• N/A

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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29 participants in 1 patient group

Telemedicine

Experimental group

Description:

Community Reinforcement and Family Training for first episode psychosis delivered via telemedicine (CRAFT-FT) with 6-8 weekly sessions of 60-minute therapy.

Treatment:

Behavioral: CRAFT-FT