Fast Reversal of Warfarin and Early Surgery in Patients With Trochanteric Hip Fracture A Case-control Study

Karolinska Institute

Status: Completed

Conditions: Warfarin Medication; Early Surgery; Trochanteric Hip Fractures

Study type: Observational

Funder types: Other

Identifiers

NCT04614090

Leif Mattisson

Details and patient eligibility

About

A retrospective case-control study. To evaluate if early surgery within 24hours of troch or subtrochanteric hip fractures using intramedullary nailing is safe in patients on warfarin treatment after fast reversal of the warfarin effect

Enrollment: 198 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Exclusion Criteria:

• Pathological fracture
• Late presentation to the hospital
• Other injuries

Trial design

198 participants in 2 patient groups

99 warfarin patients

Description:

warfarin patients were operated within 24 h with a cephalomedullary nail due to a trochanteric or subtrochanteric hip fracture. All patients on warfarin were reversed if necessary to INR≤1.5 before surgery using vitamin K and/or four-factor prothrombin complex concentrate (PCC)

99 patients without anticoagulants

Description:

As a 1:1 ratio control group matched for age, gender and surgical implant. All patients were operated within 24 h with a cephalomedullary nail due to a trochanteric or subtrochanteric hip fracture.